急性淋巴细胞白血病是儿童最常见的血液系统肿瘤,在成人中的发病率亦较高。随着医学的高速发展,我们对白血病的认识已逐步加深,针对不同类型白血病而制定相应的治疗方案可取得较好疗效,但在临床应用中,发现部分病人对糖皮质激素不敏感甚至抵抗,直接影响了治疗效果和临床预后。本文就急性淋巴细胞白血病糖皮质激素耐药的相关热点问题作一综述。 Acute lymphoblastic leukemia is the most common hematological malignancy in children and has a high prevalence in adults. With the rapid development of medicine, our understanding of leukemia has gradually deepened, and the corresponding treatment plans for different types of leukemia can achieve better efficacy, but in clinical applications, we found that some patients are not sensitive to glucocorticoid or even resistance, Directly affected the treatment effect and clinical prognosis. This article reviews the hot issues related to glucocorticoid resistance in acute lymphoblastic leukemia.