研究表明,不孕不育夫妇数量正逐步增加~([1]),据统计,全世界大约有15%~20%的育龄夫妇存在生育障碍,而男性原因导致不育的比例占40%~50%~([2])。其中精子形态异常、精子畸形率增加是导致男性不育的重要原因~([3])。当前许多学者试图从精子顶体畸形、精子DNA断裂与损伤、精子染色体异常等评价精子头部空泡与精子功能缺陷的关系~([4]),但至今精子头部空泡分类并没有统一标准,空泡的本质尚属未知领 Research shows that the number of infertility couples is gradually increasing ~ ([1]), according to statistics, there are about 15% to 20% of couples of childbearing age in the world with fertility disorders, while male causes the proportion of infertility accounted for 40% 50% ~ ([2]). Which abnormal sperm morphology, sperm abnormality rate is an important cause of male infertility ~ ([3]). At present, many scholars have tried to evaluate the relationship between sperm head vacuolization and sperm dysfunction from the acrosome sperm abnormality, sperm DNA breakage and damage, and sperm chromosome abnormalities. However, the classification of sperm head vacuolus has not been unified Standard, the nature of the bubble is still unknown collar