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本文介绍了我院采用的骨髓细胞染色体直接制备法及对18例慢粒病人的骨髓细胞染色体的检查,发现Ph′染色体阳性率达94.4％,核型均为9:22易位,1例阴性者为男性老年慢粒缓解期的病人。文章对Ph′染色体在慢粒中的发现率、临床意义、慢粒病人染色体的其他变化及急变时可出现的改变,以及慢粒病人染色体的改变与疗效的关系等问题作一简要的讨论。
This article introduced the direct chromosome preparation of bone marrow cells used in our hospital and the examination of chromosomes of bone marrow cells in 18 patients with chronic granuloma. The positive rate of Ph’ chromosome was 94.4%, the karyotype was 9:22 translocation, and 1 case was negative. The patients were elderly patients with chronic remission. This article briefly discusses the discovery rate, clinical significance of Ph’ chromosome in chromosomes, other changes in chromosomes in patients with chronic granuloma, and the changes that may occur during rapid changes, as well as the relationship between changes in chromosomes and the effect of chemotherapy in patients with chronic granuloma.