机体摄入大量的酒精后,约90%在肝脏乙醇脱氢酶的作用下转化为乙醛,并进入血液循环。肾脏是仅次于肝脏的酒精排泄器官。酒精及其代谢产物乙醛通过肾脏排泄到尿中,尿中乙醛的含量高于肝脏及血液中的含量~([1])。长期过量饮酒可导致酒精性肾损害~([2]),酒精性肾损伤以肾小管间质病变为主~([3]),但其作用机制目前尚不清楚。肾小管上皮细胞发生表型转化是发生肾间质纤维化的重要机制之一~([4])。正常肾小管上皮细胞几乎不表达α平滑肌肌动蛋白 About 90% of the body’s intake of large amounts of alcohol is converted to acetaldehyde by the action of alcohol dehydrogenase in the liver and into the bloodstream. The kidneys are second to the liver’s alcohol excretion organs. Acetaldehyde, an alcohol and its metabolite, is excreted into the urine through the kidneys. The content of acetaldehyde in the urine is higher than that in the liver and blood (1). Long-term excessive alcohol consumption can lead to alcoholic renal damage ~ ([2]), alcoholic renal injury to tubulointerstitial lesions ~ ([3]), but its mechanism of action is unclear. Phenotypic transformation of tubular epithelial cells is an important mechanism of renal interstitial fibrosis ~ ([4]). Normal tubular epithelial cells express little α-smooth muscle actin