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目的观察左乙拉西坦对青少年癫癇部分性发作患者精神状态及心理状态的影响。方法选取作者医院神经内科收治的72例癫癇部分性发作患者,采用随机数字表法均分为观察组(n=36)与对照组(n=36)。对照组单用奥卡西平治疗,观察组在此基础上加用左乙拉西坦。治疗16周后统计两组患者治疗期内平均每周部分性癫癇发作频率,并比较两组患者的Epworth嗜睡量表(Epworth sleepiness scale,ESS)评分、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分及汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分及不良反应发生情况。结果治疗期内观察组的平均每周部分性癫癇的发作频率明显低于对照组,组间比较差异具有统计学意义(P<0.01);但是治疗结束后观察组的ESS、HAMA与HAMD评分均明显高于对照组,组间比较差异具有统计学意义(P<0.01),两组患者不良反应发生情况比较差异无统计学意义(P>0.05)。结论左乙拉西坦有助于降低青少年患者部分性癫癇发作频率,但也会引起嗜睡、焦虑及抑郁等精神和心理问题,临床使用应权衡利弊。
Objective To observe the effects of levetiracetam on mental status and mental status in patients with partial seizures in adolescents. Methods Seventy-two patients with partial epilepsy were enrolled in the Department of Neurology, Hospital of Internal Medicine. The patients were randomly divided into observation group (n = 36) and control group (n = 36). The control group was treated with oxcarbazepine only, and the observation group was given levetiracetam on the basis of this. After 16 weeks of treatment, the mean weekly partial seizure frequency during the treatment period was calculated. Epworth sleepiness scale (ESS) score, Hamilton anxiety scale (HAMA) score, Score and Hamilton depression scale (HAMD) scores and adverse reactions. Results The frequency of partial weekly epileptic seizures in the observation group was significantly lower than that in the control group during the treatment period (P <0.01). However, the scores of ESS, HAMA and HAMD in the observation group after the treatment were all significantly lower than those in the control group The difference between the two groups was statistically significant (P <0.01). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion Levetiracetam can help reduce the frequency of partial seizures in adolescents, but it may also lead to mental and psychological problems such as drowsiness, anxiety and depression. The pros and cons should be weighed against clinical use.