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目的:观察天钩降压胶囊对肾血管性高血压大鼠的血压的影响并初步探讨其作用机制。方法:将72只Wistar大鼠随机分为正常对照组、模型组、卡托普利组(0.03 g.kg-1)、天钩降压胶囊低、中、高剂量组(5.4,10.8,21.6 g.kg-1)。采用无创血压仪测量鼠尾动脉血压;采用放射免疫法测定大鼠血中PRA,AngⅡ,ALD,6-酮-前列腺F1α,ET和TXB2的含量;采用硝酸还原酶法测定大鼠血中NO的含量。结果:模型组收缩压、舒张压和平均压明显升高,大鼠血中PRA,AngⅡ,ALD明显降低,ET水平明显增高;天钩降压胶囊能明显降低模型大鼠的血压,提高大鼠血中肾素活性,降低大鼠血中ET含量,升高NO含量。结论:天钩降压胶囊具有降低肾性高血压模型大鼠血压的作用,其降低血压的机制可能与其调控模型大鼠RAAS系统的分泌以及改善血管内皮的功能有关。
Objective: To observe the effect of Tian hookjiangya capsule on blood pressure in renovascular hypertensive rats and to explore its mechanism. Methods: 72 Wistar rats were randomly divided into normal control group, model group, captopril group (0.03 g.kg-1), Tiangujianjiangya capsule low, medium and high dose group (5.4,10.8,21.6 g.kg-1). The rat tail blood pressure was measured by using a noninvasive blood pressure meter. The levels of PRA, AngⅡ, ALD, 6-keto-prostatic F1α, ET and TXB2 were determined by radioimmunoassay. Nitric oxide content. Results: The systolic blood pressure, diastolic blood pressure and mean pressure of the model group were significantly higher than those of the model group, the levels of PRA, AngⅡ and ALD were significantly decreased and the ET level was significantly increased in the model group. Blood renin activity, reduce ET content in blood, increase NO content. Conclusion: Tian hookjiangya capsule can reduce the blood pressure in the rat model of renal hypertension, and its mechanism of lowering blood pressure may be related to regulating the secretion of the RAAS system and improving the function of the vascular endothelium.