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目的了解产β-内酰胺酶大肠埃希菌在医院的检出情况和产酶菌株对药物的耐药性,为大肠埃希菌感染后的治疗提供合理的用药依据。方法收集临床分离的98株大肠埃希菌,细菌鉴定采用XIN-KE微生物鉴定仪;采用试纸法检测产酶株的阳性率;采用纸片法测定产酶阳性株对12种抗生素的耐药程度,分析其耐药性。结果98株大肠埃希菌中检出产酶菌株82株,阳性率为83.7%。产酶阳性株的标木来源以伤口分泌物为主,其次为尿液和痰液。科室以普外科、泌尿外科为主。产酶菌株对多种抗生素均表现出较强耐药性,其中对氨苄西林的耐药率最高为85.4%,对亚胺培南不耐药。结论临床分离大肠埃希菌产β-内酰胺酶检出率高,耐药率高,治疗产β-内酰胺酶菌感染应根据体外药敏试验结果选用敏感抗生素。
Objective To understand the detection of β-lactamase-producing Escherichia coli in hospitals and drug-resistant strains of drug-producing strains, and to provide a reasonable basis for the treatment of Escherichia coli after infection. Methods 98 clinical isolates of Escherichia coli were collected. The bacteria were identified by XIN-KE microbial identification instrument. The positive rate of enzyme-producing strains was detected by the strip paper method. The drug resistance of positive strains producing 12 kinds of antibiotics , Analysis of its resistance. Results Among the 98 strains of Escherichia coli isolated, 82 strains of producing enzymes were detected, the positive rate was 83.7%. The main source of enzyme-producing strains of wood with wound secretions, followed by urine and sputum. Department of general surgery, urology mainly. The enzyme-producing strains showed strong resistance to a variety of antibiotics, of which the highest rate of resistance to ampicillin was 85.4%, which was not resistant to imipenem. Conclusion The clinical isolates of Escherichia coli producing high detection rate of β-lactamase, high resistance rate, the treatment of β-lactamase-producing bacteria should be based on the results of in vitro susceptibility testing of sensitive antibiotics.