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目的:探讨中老年人群血浆瘦素水平(Lep)与中心性肥胖及代谢综合征(MS)的关系。方法:随机选择2005年体检的在职、退休公务员82人,分为中心性肥胖组与对照组。分别测定两组腰围(WC)、甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、空腹血糖(FBG)、空腹胰岛素(FINS)、瘦素(Lep)以及游离脂肪酸(FFA)水平。结果:肥胖组血浆瘦素水平较对照组显著增高,且与WC呈正相关,同时TG、HDL、FBG、FINS、WC均与对照组有显著差异。肥胖组出现MS的发病率亦较对照组有显著性差异。结论:中心性肥胖对代谢综合征的发生具有重要的临床意义,而血浆瘦素水平升高可能是胰岛素抵抗,中心性肥胖乃至代谢综合征的发生、发展的重要因素之一。
Objective: To investigate the relationship between plasma leptin level (Lep) and central obesity and metabolic syndrome (MS) in middle-aged and elderly people. Methods: 82 randomly selected serving and retired civil servants in 2005 were divided into central obesity group and control group. The serum levels of WC, TG, TC, HDL, LDL, FBG, FINS, (Lep) and free fatty acid (FFA) levels. Results: Plasma leptin levels in obese group were significantly higher than those in control group, and were positively correlated with WC, while TG, HDL, FBG, FINS and WC were significantly different from those in control group. The incidence of MS in the obese group also showed significant difference compared with the control group. CONCLUSION: Central obesity has important clinical significance for the development of metabolic syndrome. Elevated plasma leptin level may be one of the important factors in the occurrence and development of insulin resistance, central obesity and metabolic syndrome.