在内皮源性舒张因子(EDRF)内皮源性舒张因子被发现后,对其在机体病理生理中的意义也不断得到重视。现已证明,EDRF 的产生受损与机体多重病理生理状态有关,如各种休克、缺血与再灌注、动脉粥样硬化(AS)、高血压、心力衰竭等。本文主要概述 EDRF与 PTCA 后再狭发生的有关因素之间的关系,旨在阐明 EDRF 的产生受损对再狭窄发生的影响。 Endothelium-derived relaxing factor (EDRF) after the discovery of endothelium-derived relaxing factor, its significance in the pathophysiology of the body also continue to be attention. It has been demonstrated that EDRF is impaired by multiple pathophysiological states of the body, such as various shocks, ischemia and reperfusion, atherosclerosis (AS), hypertension, and heart failure. This article summarizes the relationship between EDRF and factors related to restenosis after PTCA to elucidate the impact of impaired EDRF on the occurrence of restenosis.