目的:探讨子宫切除手术后一年半年患者绝经综合症发生的情况和卵巢功能的变化。方法:选择我院2010年1月-2012年1月进行诊断治疗的女性患者40例,其中以因子宫良性病变进行子宫切除手术后保留双侧卵巢的患者40例为观察组,以同龄因阴道炎就诊的女性40例为对照组,通过问卷调查和电话随访来了解其绝经综合症发病情况,同时对两组患者的卵泡刺激素、性腺激素雌二醇、黄体生成素水平进行检测。结果:子宫切除后一年半观察组绝经综合症发生率为32.5%,对照组为7.5%。观察组中有重度忧郁多疑患者,失眠、乏力、烦躁易怒患者各6、6、7例,明显高于对照组1、1、2例,且两组差异显著,有统计学意义(P<0.05);两组卵泡刺激素、性腺激素雌二醇、黄体生成素水平相比,数据对比具有显著差异,有统计学意义(P<0.05)。结论:子宫切除手术后一年半女性较同龄保有子宫的女性出现绝经综合症症状时间早,主观精神神经系统症状更为明显,且出现卵巢功能提早减退的情况。 Objective: To investigate the changes of menopausal syndrome and ovarian function in patients with hysterectomy one year and a half after surgery. Methods: Forty female patients diagnosed and treated in our hospital from January 2010 to January 2012 were enrolled in this study. Forty patients with bilateral ovaries after hysterectomy due to benign uterine disease were selected as the observation group, Forty infants with inflammation were selected as the control group. The incidence of menopause syndrome was investigated by questionnaire survey and telephone follow-up. The levels of follicle-stimulating hormone, sex hormones estradiol and luteinizing hormone in both groups were also tested. Results: In the year and a half after hysterectomy, the incidence of menopausal syndrome was 32.5% in the observation group and 7.5% in the control group. In the observation group, there were 6, 6, and 7 cases of severe depression and paranoidness, insomnia, fatigue and irritability in each group, which were significantly higher than those in the control group (1,1,2 cases). There was significant difference between the two groups (P < 0.05). There was significant difference between the two groups in the levels of follicle stimulating hormone, sex hormones estradiol and luteinizing hormone (P <0.05). CONCLUSIONS: Women in the year and a half after hysterectomy had older menopausal syndromes than women of the same age, symptoms of the subjective neuropsychiatric system were more obvious, and ovarian function was reduced earlier.