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观察６６例慢性萎缩性胃炎伴异型增生的胃粘膜活检标本的幽门螺杆菌感染情况。结果：慢性活动性萎缩性胃炎的感染率显著高于慢性静止性萎缩性胃炎（Ｐ＜０．００５），各级异型增生间的感染率无差别（Ｐ＞０．０５），慢性活动性萎缩性胃炎伴轻、中度异型增生者显著高于慢性静止性茎缩性胃炎（Ｐ＜０．００５）。认为：ＨＰ感染与胃粘膜上皮异型增生有密切关系，其感染引起胃癌发生的可能过程为幽门螺杆菌感染正常胃粘膜→急性胃炎→慢性浅表性胃炎→慢性萎缩性胃炎→异型增生→胃癌。
Observed 66 cases of chronic atrophic gastritis with dysplasia gastric mucosa biopsy samples of Helicobacter pylori infection. Results: The infection rate of chronic active atrophic gastritis was significantly higher than that of chronic static atrophic gastritis (P<0.005). There was no difference in the infection rate between different levels of dysplasia (P>0.05), chronic active atrophy. Gastritis with mild to moderate dysplasia was significantly higher than chronic static stem gastritis (P<0.005). It is believed that HP infection is closely related to dysplasia of gastric epithelium. The possible process of infection caused by gastric infection is H. pylori infection in normal gastric mucosa → acute gastritis → chronic superficial gastritis → chronic atrophic gastritis → dysplasia → gastric cancer.