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目的:探讨补体因子H(CFH)基因1277T/C多态性与早发冠心病的相关性。方法:选择早发冠心病患者(男<55岁,女<60岁)125例、非冠心病对照组126例,收集研究对象临床资料,检测生化指标。采用聚合酶链反应-连接酶检测反应(PCR-LDR)分析CFH基因1277T/C多态性。结果:早发冠心病组吸烟、高血压病及糖尿病比例较对照组明显增多(P<0.05)。早发冠心病组与对照组CFH基因1277T/C中TT、TC、CC基因型频率分布差异无统计学意义(χ2=0.081,P>0.05)。结论:CFH基因1277T/C多态性可能与早发冠心病的易感性无关。
Objective: To investigate the association of complement factor H (CFH) gene 1277T / C polymorphism with premature coronary heart disease. Methods: 125 patients with premature coronary heart disease (male <55 years, female <60 years old) and 126 non-coronary heart disease control subjects were enrolled in this study. Clinical data were collected and biochemical indexes were detected. Polymerase chain reaction - ligase detection reaction (PCR-LDR) was used to analyze the CFH gene 1277T / C polymorphism. Results: The prevalence of smoking, hypertension and diabetes in premature coronary heart disease group was significantly higher than that in control group (P <0.05). There was no significant difference in the frequency distribution of TT, TC and CC genotypes between CFH gene 1277T / C in premature coronary heart disease group and control group (χ2 = 0.081, P> 0.05). Conclusion: The 1277T / C polymorphism of CFH gene may not be related to the susceptibility to premature coronary heart disease.