论文部分内容阅读
在广西田阳县中学生中，分６组共６９７人进行了Ｏ１３９型霍乱菌苗与Ｏ１群霍乱菌苗的双盲、有对照的人体反应现场观察。结果表明，不加铝佐剂的Ｏ１３９型霍乱菌苗及Ｏ１群霍乱菌苗，不论是低剂量组（两剂全程接种４５亿菌体）抑或常剂量组（全程接种９０亿）接种人群均可产生１０～２５％的体温呈轻度升高的弱反应，并且同种菌苗的两剂量组的反应率无显著差异；第一剂接种的反应率（１９～２５％）较第二剂接种的（１０～１５％）高，Ｐ＜０．０５；接种局部反应轻微，只有个别受试者出现直径小于１５ｍｍ的硬结；加佐剂的Ｏ１群吸附霍乱菌苗的反应较其它组强。结果证实，甲醛灭活的Ｏ１３９型霍乱菌苗和Ｏ１群霍乱菌苗是安全的，接种人体对之具有良好的耐受性
Among Tianyang middle school students in Guangxi, a total of 697 patients in 6 groups were enrolled in a double-blind, controlled human response to O139 cholera vaccine and O1 cholera vaccine. The results showed that the cholera vaccine of type O139 without cholera and the cholera vaccine of group O1 could be vaccinated in both the low-dose group (two doses of 4.5 billion cells in the whole course) or the normal dosage group (inoculation of 9 billion in the whole course) There was no significant difference in response rates between the two doses of the same vaccine; the response rate of the first dose (19-25%) was higher than that of the second dose (10-15%), P <0.05. The local inoculation was mild with only induration of less than 15 mm in diameter in individual subjects. The response of cholerae vaccine to O1 group with adjuvant was stronger than that of other groups. As a result, it was confirmed that formaldehyde-inactivated cholera vaccine type O139 and cholera vaccine type O1 were safe and well-tolerated by human inoculation