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目的探讨小剂量尿激酶联合阿司匹林治疗急性脑梗死的临床疗效及对预后的影响。方法选取我院2008年5月-2012年5月诊治的急性脑梗死患者68例,随机分为两组,对照组33例给予常规控制血压、改善脑微循环及保护脑细胞等治疗,并给予小分子肝素溶栓治疗,治疗组35例在常规治疗基础上给予小分子尿激酶及阿司匹林治疗,观察两组临床疗效、血小板计数、血沉(ESR)及神经功能缺损评分的变化。结果治疗组有效率94.28%,显著高于对照组的75.76%,差异有统计学意义(P<0.05),治疗组血小板计数与ESR分别为164.2±20.4×109/L和20.7±2.7mm/h,均明显改善,显著优于对照组,差异有统计学意义(P<0.05)。结论小剂量尿激酶联合阿司匹林治疗急性脑梗死的临床疗效显著,患者预后明显改善。
Objective To investigate the clinical efficacy of low-dose urokinase combined with aspirin in the treatment of acute cerebral infarction and its effect on prognosis. Methods A total of 68 acute cerebral infarction patients diagnosed and treated in our hospital from May 2008 to May 2012 were randomly divided into two groups. The control group was given routine blood pressure control, cerebral microcirculation improvement and brain cell protection, In the treatment group, 35 patients were treated with small molecule urokinase and aspirin on the basis of routine treatment. The clinical curative effect, platelet count, ESR and neurological deficit scores of the two groups were observed. Results The effective rate of the treatment group was 94.28%, which was significantly higher than that of the control group (75.76%), the difference was statistically significant (P <0.05). The platelet count and ESR of the treatment group were 164.2 ± 20.4 × 109 / L and 20.7 ± 2.7mm / h , Significantly improved, significantly better than the control group, the difference was statistically significant (P <0.05). Conclusion The clinical efficacy of low-dose urokinase combined with aspirin in the treatment of acute cerebral infarction was significant, and the prognosis of patients was significantly improved.