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目的：观察硝苯啶治疗原发性高血压患者（ＥＨ）后对血清甲状旁腺素（ＰＴＨ）和血浆内皮素（ＥＴ）的影响。方法：采用放射免疫分析方法对４１例ＥＨ和３５例正常对照组血清ＰＴＨ和血浆ＥＴ含量的测定。结果：治疗前ＰＴＨ和ＥＴ含量均较对照组明显增加（Ｐ＜０．０１～０．００１）；ＰＴＨ与平均动脉压（ＭＡＰ）、ＥＴ与ＭＡＰ及ＰＴＨ与ＥＴ之间均呈明显的正相关（ｒ值分别为０．６９、０．７６和０．６５，Ｐ值均＜０．０１）。用硝苯啶治疗１４ｄ后，ＰＴＨ和ＥＴ均明显降低（Ｐ＜０．０１～０．００１）。结论：ＰＴＨ和ＥＴ可能参与了高血压的发生过程
Objective: To observe the effects of nifedipine on serum parathyroid hormone (PTH) and plasma endothelin (ET) in patients with essential hypertension (EH). Methods: The contents of serum PTH and plasma ET in 41 cases of EH and 35 cases of normal control group were determined by radioimmunoassay. Results: The contents of PTH and ET before treatment were significantly higher than those in control group (P <0.01-0.001). There was a significant positive correlation between PTH and mean arterial pressure (MAP), ET, MAP, PTH and ET (R values were 0.69,0.76 and 0.65 respectively, P <0.01). After treatment with nifedipine for 14 days, PTH and ET were significantly decreased (P <0.01 ~ 0.001). Conclusion: PTH and ET may be involved in the pathogenesis of hypertension