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结核分枝杆菌感染每年导致200万人口死亡,而化疗已经产生了严重的广泛传播的耐药性。信号转导系统是细菌适应周围环境变化的重要分子机制,是否介导细菌耐药性的产生,尚无清楚的认识。本文主要介绍了结核分枝杆菌的12对二元信号转导系统并分析了其与耐药性产生的关系。通过对近期研究的分析,我们发现Mpr B/A、PhoR/P、DosR/S/T、Sen X3/Reg X3、Mtr B/A五对二元信号转导系统有可能通过不同的机制使结核分枝杆菌对抗结核药物发生耐药性,因此二元信号转导系统是有效的调控靶位点,有可能应用小分子化合物靶向调节二元信号转导途径以逆转耐药。
Mycobacterium tuberculosis causes an annual death toll of 2 million people, and chemotherapy has resulted in serious, widespread spread of resistance. Signal transduction system is an important molecular mechanism of bacteria to adapt to changes in the surrounding environment, whether to mediate the emergence of bacterial resistance, there is no clear understanding. In this paper, 12 pairs of binary signal transduction systems of Mycobacterium tuberculosis were introduced and their relationship with drug resistance was analyzed. Through the analysis of recent studies, we found that five pairs of binary signal transduction systems of Mpr B / A, PhoR / P, DosR / S / T, Sen X3 / Reg X3 and Mtr B / A may make tuberculosis Mycobacterium tuberculosis drug resistance, and therefore binary signal transduction system is an effective regulatory target sites, it is possible to use small molecule compounds targeted regulation of binary signal transduction pathway to reverse drug resistance.