论文部分内容阅读
3-Methyl-5-(2-methylphenyl)-1,3,4-oxadiazol-2(3H)-one(6) and N,N-diethyl-2-(2-methylbenzoyl)-hydrazinecarboxamide(7) were designed and synthesized from 5-(2-methylphenyl)-1,3,4-oxadiazol-2(3H)-one(5) by substituting and ring-opening, respectively. The target compounds were confirmed by IR, 1H NMR spectroscopy, MS, elemental analysis and single-crystal X-ray diffraction. Compound 6(C10H10N2O2, Mr = 190.20) crystallizes in the triclinic system, space group P 1 with a = 7.4645(16), b = 10.868(2), c = 12.970(3) A, α= 110.542(2), β= 98.142(2), γ=99.766(2)°, V = 947.7(3) A3, Z = 4, F(000) = 400, Dc = 1.333 g/cm3, μ= 0.095 mm-1, the final R =0.0550 and wR = 0.1483 for 2956 observed reflections with I > 2γ(I). Compound 7(C13H19N3O2, Mr= 249.31) crystallizes in the monoclinic system, space group C2/c with a = 18.926(3), b =12.1853(17), c = 14.740(2) o,(I) = 125.6380(10)°, V = 2762.7(7) A3, Z = 8, F(000) = 1072, Dc=1.199 g/cm3, μ= 0.083 mm-1, the final R = 0.0554 and w R = 0.1468 for 2395 observed reflections with I > 2σ(I). The preliminary bioassay results indicate that compound 6 exhibits notable fungicidal activities against Fusarium graminearum, Botrytis cinerea, Rhizoctonia cerealis and Colletotrichum capsici at the concentration of 100 μg/mL.
3-Methyl-5- (2-methylphenyl) -1,3,4-oxadiazol-2 (3H) -one (6) and N, N-diethyl-2-methylbenzoyl-hydrazinecarboxamide and synthesized from 5- (2-methylphenyl) -1,3,4-oxadiazol-2 (3H) -one (5) by substituting and ring- opening, respectively. The target compounds were confirmed by IR, 1H NMR spectroscopy, MS (C10H10N2O2, Mr = 190.20) crystallizes in the triclinic system space group P 1 with a = 7.4645 (16), b = 10.868 (2), c = 12.970 A = α = 110.542 (2) β = 98.142 (2) γ = 99.766 (2) ° V = 947.7 (3) A3 Z = 4 F (000) = 400 Dc = 1.333 g / cm3, μ = 0.095 mm-1, the final R = 0.0550 and wR = 0.1483 for 2956 observed reflections with I> 2γ (I). Compound 7 (C13H19N3O2, Mr = 249.31) crystallizes in the monoclinic system, space group C2 / c with a = 18.926 (3), b = 12.1853 (17), c = 14.740 (2) o, (I) = 125.6380 (10) °, V = 2762.7 A3, Z = 8, F 1072, Dc = 1.199 g / cm3, μ = 0.083 mm-1, the final R = 0.0554 and w R = 0.1468 for 239 5 pointed reflections with I> 2σ (I). The preliminary bioassay results indicate that compound 6 exhibits notable fungicidal activities against Fusarium graminearum, Botrytis cinerea, Rhizoctonia cerealis and Colletotrichum capsici at the concentration of 100 μg / mL.