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目的通过分析子痫前期患者及正常孕妇血浆白细胞介素18(IL-18)和C反应蛋白水平,以探讨二者与子痫前期的关系。方法选择35例子痫前期患者(其中轻度子痫前期20例,重度子痫前期15例)及40例正常妊娠的孕妇,在空腹时抽血3 ml,用夹心酶联免疫法检测血浆IL-18水平,采用透射比浊法检测血清C反应蛋白水平。结果子痫前期孕妇血浆IL-18水平和C反应蛋白水平明显高于正常孕妇(均P<0.05);重度子痫前期孕妇血浆IL-18水平明显高于轻度子痫前期孕妇(P<0.05),而C反应蛋白水平与轻度子痫前期孕妇相比差异无统计学意义(P>0.05)。结论 IL-18和C反应蛋白水平在子痫前期明显升高,IL-18与子痫前期疾病的严重性相关。
Objective To investigate the relationship between the levels of interleukin 18 (IL-18) and C-reactive protein in preeclampsia and normal pregnant women and their relationship with preeclampsia. Methods 35 pregnant women with preeclampsia (20 with mild preeclampsia and 15 with severe preeclampsia) and 40 normal pregnant women were enrolled in this study. Blood samples were drawn from 3 ml of fasting serum and the levels of IL- 18 levels, using transmission nephelometry serum C-reactive protein levels. Results The levels of plasma IL-18 and C-reactive protein in preeclampsia were significantly higher than those in normal pregnant women (all P <0.05). The levels of plasma IL-18 in severe preeclampsia were significantly higher than those in mild preeclampsia (P <0.05) ), While the level of C-reactive protein in pregnant women with mild preeclampsia was no significant difference (P> 0.05). Conclusion The levels of IL-18 and C-reactive protein are significantly increased in preeclampsia, and IL-18 is associated with the severity of preeclampsia.