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目的比较两种剂量肾上腺素在长时程室颤家猪心肺复苏中的疗效。方法将16头家猪随机分为两组,分别为标准剂量肾上腺组(0.02mg/kg),大剂量肾上腺组(0.1mg/kg)。采用体外电击法制备室颤动物模型,并于8min室颤后依次给予2min心肺复苏,除颤,肾上腺素。观察血流动力学和自主循环恢复情况。结果自主循环恢复率两组一样,两组间血流动力学和除颤成功率差异无统计学意义。结论大剂量肾上腺素没有改善血流动力学,也没有提高除颤成功率和自主循环恢复率。
Objective To compare the effects of two doses of epinephrine on cardiopulmonary resuscitation in long-term VF rats. Methods Totally 16 domestic pigs were randomly divided into two groups: standard dose adrenal group (0.02mg / kg) and high dose adrenal group (0.1mg / kg). The model of ventricular fibrillation was prepared by electric shock method in vitro, and cardiopulmonary resuscitation, defibrillation and adrenaline were given in 2 min after ventricular fibrillation in 8 min. Hemodynamics and spontaneous circulation recovery were observed. Results The rate of spontaneous circulation recovery was the same in both groups. There was no significant difference in the success rate of hemodynamics and defibrillation between the two groups. Conclusion High dose of epinephrine did not improve hemodynamics, nor did it improve the success rate of defibrillation and spontaneous circulation recovery rate.