以往曾接种灭活麻疹疫苗(KMV)的儿童可因感染野麻疹病毒而发生非典型麻疹。目前很多报道表明,接种KMV和发生非典型麻疹之间的间期似在逐渐延长。本文报道2例同胞姊弟在接种灭活麻疹疫苗后16年发生非典型麻疹,其间隔时间较以往任何报道都长。同时提示在某些人中给予活麻疹疫苗并不提供持久的保护作用。对4例同胞姊弟进行了观察,他们曾先后接种过KMV,每月1ml,共2次。一月 Children who have previously inactivated measles vaccine (KMV) may develop atypical measles due to their infection with the measles virus. Many reports show that the interval between vaccination of KMV and atypical measles seems to be gradually prolonged. This article reports that two siblings had atypical measles 16 years after inoculation of an inactivated measles vaccine at intervals longer than ever reported. It also suggests that giving measles vaccine in some people does not provide lasting protection. Four sibling siblings were observed, they had inoculated KMV, 1ml per month, a total of 2 times. January