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目的了解急性缺血性脑卒中患者幽门螺杆菌(Hp)感染状况,分析Hp感染与血脂水平的关系。方法选取2012年3月至2013年5月急性缺血性脑卒中患者135例(脑梗死组),以及健康体检者40例(对照组),检测并比较两组Hp阳性率、超敏C-反应蛋白(hs-CRP)阳性率。按照Hp检测结果将急性缺血性脑卒中组分为Hp阳性组(A组)及阴性组(B组),比较A、B两组患者血清hs-CRP、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDLC)、高密度脂蛋白(HDL-C)水平。分析血清Hp-Ig G阳性与TC、hs-CRP的相关性。结果脑梗死组患者Hp感染率(48.2%vs 32.5%)、血清hs-CRP阳性率(31.1%vs 7.5%)明显高于对照组,差异有统计学意义(P<0.05,P<0.01)。A、B两组血清hs-CRP、TG及LDL-C比较差异均有统计学意义(P<0.05,P<0.01),而TC及HDL-C水平无明显差异(P均>0.05)。Hp感染与TG水平、hs-CRP水平均呈正相关(r=0.439,P<0.01;r=0.563,P<0.01)。结论 Hp感染与急性缺血性脑卒中发病有关,与血脂水平呈正相关。
Objective To understand the status of Helicobacter pylori (Hp) infection in patients with acute ischemic stroke and to analyze the relationship between Hp infection and blood lipid levels. Methods From March 2012 to May 2013, 135 patients with acute ischemic stroke (cerebral infarction group) and 40 healthy subjects (control group) were enrolled in this study. The positive rate of Hp and the sensitivity of C- Reactive protein (hs-CRP) positive rate. The acute ischemic stroke group was divided into Hp positive group (group A) and negative group (group B) according to the results of Hp test. The serum hs-CRP, triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDLC), high density lipoprotein (HDL-C) levels. Analysis of serum Hp-Ig G positive and TC, hs-CRP correlation. Results The Hp infection rate (48.2% vs 32.5%) and serum hs-CRP positive rate (31.1% vs 7.5%) in patients with cerebral infarction were significantly higher than those in control group (P <0.05, P <0.01). There were significant differences in serum hs-CRP, TG and LDL-C levels between groups A and B (P <0.05, P <0.01), while there was no significant difference between TC and HDL-C levels (P all> 0.05). Hp infection was positively correlated with TG level and hs-CRP level (r = 0.439, P <0.01; r = 0.563, P <0.01). Conclusion Hp infection is associated with the onset of acute ischemic stroke and positively correlated with the level of serum lipids.