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目的 研究胆囊排空及血浆胃肠激素水平变化在功能性消化不良 (FD)发病机制中的作用。方法 采用放射性核素序列成像和放免技术检测 2 0例健康志愿者 (对照组 )和 32例功能性消化不良患者 (FD组 )空腹及餐后胆囊排空指数和血浆胃动素 (MTL)、胆囊收缩素 (CCK)、血管活性肠肽(VIP)和生长抑素 (SS)水平。结果 FD组空腹及餐后胆囊排空指数均明显低于对照组 ,差异有非常显著性 (P <0 .0 0 1) ;FD组空腹及餐后血浆MTL值均低于对照组 ,差异有非常显著性 (P <0 .0 0 1) ,MTL值与胆囊排空指数呈正相关 (r空腹 =0 .82 ,P <0 .0 1,r餐后 =0 .94,P <0 .0 1) ;FD组空腹血浆CCK值与对照组比较 ,差异无显著性 (P >0 .0 5 ) ,餐后差异有非常显著性 (P <0 .0 0 1) ,CCK值与胆囊排空指数呈显著正相关 (r =0 .97,P <0 .0 1) ;FD组空腹与餐后血浆VIP值均高于对照组 ,差异有非常显著性 (P <0 .0 0 1) ,VIP值与胆囊排空指数呈负相关 (r空腹 =- 0 .81,P <0 .0 1,r餐后 =- 0 .47,P <0 .0 1) ;FD组空腹及餐后血浆SS值与对照组相比 ,差异无显著性 (P >0 .0 5 )。结论 (1)FD患者存在空腹及餐后胆囊排空下降 ,血浆促胃肠动力激素 (MTL、CCK)水平下降和抑制胃肠动力激素 (VIP)水平升高 ,可能是其病因和发病机制之一 ;(2 )放射性核
Objective To study the role of changes of gallbladder emptying and plasma gastrointestinal hormones in the pathogenesis of functional dyspepsia (FD). Methods The fasting and postprandial gallbladder emptying index and plasma motilin (MTL) in 20 healthy volunteers (control group) and 32 patients with functional dyspepsia (FD group) were detected by radionuclide sequence imaging and radioimmunoassay. CCK, VIP, and SS. Results The fasting and postprandial gallbladder emptying indexes in FD group were significantly lower than those in control group (P <0.01). The fasting and postprandial plasma MTL values in FD group were lower than those in control group (P <0.01). There was a positive correlation between MTL value and gallbladder emptying index (r = 0.82, P <0.01, r = 0.94, P < 1). There was no significant difference in fasting plasma CCK between FD group and control group (P> 0.05), postprandial difference was significant (P <0.001) (R = 0.97, P <0.01). The fasting and postprandial plasma VIP values in FD group were significantly higher than those in control group (P <0.01) The VIP value was negatively correlated with the Gallbladder emptying index (r = - 0.81, P <0.01, r = -0.47, P <0.01). The fasting and postprandial plasma SS value compared with the control group, the difference was not significant (P> 0.05). Conclusions (1) FD patients have decreased fasting and postprandial gallbladder emptying, decreased plasma levels of gastrointestinal motility hormones (MTL, CCK) and inhibition of gastrointestinal motility hormone (VIP), which may be the etiopathogenisis and pathogenesis One; (2) radioactive nuclear