研究表明,在pH2.36的弱酸性条件下,当有还原性药物如盐酸四环素存在时多壁碳纳米管能催化还原氯金酸并生成金纳米微粒.通过检测反应生成的金纳米微粒的等离子共振光散射信号,建立了快速、简便的盐酸四环素催化共振光散射分析方法.方法的线性范围为4~26μmol/L,相关系数(r)为0.9955,检出限(3σ)为6.0nmol/L.将该方法用于盐酸四环素片剂分析,平均加标回收率为101.9%;用于尿液分析,加标回收率为98.3%~102.0%. The results showed that multi-walled carbon nanotubes (CNTs) can catalyze the reduction of chloroauric acid and generate gold nanoparticles when a reducing drug such as tetracycline hydrochloride exists in the presence of a reducing agent such as tetracycline hydrochloride at pH 2.36.After detecting the plasma of gold nanoparticles The linearity of the method was 4 ~ 26μmol / L, the correlation coefficient (r) was 0.9955, the detection limit (3σ) was 6.0nmol / L The method was applied to the analysis of tetracycline hydrochloride tablets with the average recoveries of 101.9% and the recoveries of 98.15% ~ 102.0% for urine analysis.