以固体超强酸树脂为催化剂合成2-氯丙酸异丙酯,研究了催化剂的用量、反应起始原料物质的量比、反应时间、带水剂种类及用量对酯化反应的影响,确定了合成2-氯丙酸异丙酯的最佳反应条件为:n(异丙醇)∶n(环己烷)∶n(催化剂)∶n(2-氯丙酸)=5∶6.5∶0.3∶1,反应时间为2h,在此条件下,2-氯丙酸异丙酯的收率可达到95%,纯度达到99%以上。 The synthesis of isopropyl 2-chloropropionate with solid superacid as catalyst was studied. The effects of the amount of catalyst, the ratio of starting materials, the reaction time, the type and amount of water-carrying agent on the esterification reaction were studied. The optimum reaction conditions for the synthesis of isopropyl 2-chloropropionate are: n (isopropanol): n (cyclohexane): n (catalyst): n 1, the reaction time is 2h. Under this condition, the yield of isopropyl 2-chloropropionate can reach 95%, and the purity reaches more than 99%.