患者女,75岁。因右上肢粉碎性骨折入院治疗。既往无药物不良反应史。骨折后为预防感染静脉给予青霉素后,转为菌必治50ｍｇ/ｋｇ体重(豪夫迈-罗氏有限公司,批号:970504)静脉滴注2ｄ后,出现全身皮疹及尿少、肾功能衰竭。经停药后给予抗过敏药,透析抗肾衰后逐渐痊愈。患者男,59岁 Female patient, 75 years old. Due to the right upper extremity comminuted fracture hospitalization. Past history of adverse drug reactions. After the fracture to prevent infection intravenous penicillin, was converted to bacteriostatic 50mg / kg body weight (Hoffman - Roche Co., batch number: 970504) intravenous drip 2d, the whole body rash and oliguria, renal failure. Anti-allergy drugs were given after discontinuation, and gradually recovered after dialysis against renal failure. Male patient, 59 years old