论文部分内容阅读
本文研究了巴西日本圆线虫在大、小白鼠(以下简称大鼠、小鼠)体内发育的规律,认为大鼠可作为筛选药物适宜的动物.试验方法为每组4只大鼠,每鼠定量接种该虫感染期幼虫400条.于感染后第11或12日给药,给药后48小时解剖,检视肠中残存虫数,并收集给药后2天内鼠粪成虫.用检获总虫数与粪便中掏出虫数加上肠中残存虫数来比较,计算出有效率或直接疗效.作者初步实验了10种已知有效驱钩药物和广谱驱虫药物,结果除土荆芥油和stilbazium iodide外,皆获得良好效果.5种已知非驱钩药物则皆无效.本方法所用粪便掏虫结合解剖检虫法,不需要设对照组,较国外的方法简便经济,而且准确可靠.
In this paper, we studied the law of the development of C. elegans in large and small mice (hereinafter referred to as rats and mice) and considered that rats could be used as appropriate animals for screening drugs. The experimental method was 4 rats in each group, The larvae were inoculated with 400 infective stage larvae on the 11th or 12th day after infection, dissected 48 hours after the administration, the numbers of remaining worms in the intestines were examined, and the feces of the feces were collected within 2 days after the administration, And feces in the number of insects plus the number of insects in the intestine to compare the number of residual to calculate the efficiency or direct effect of the author of the preliminary experiment of 10 known effective drugs and broad-spectrum drive hook deworming drugs, the results in addition to soil catharanthus oil And stilbazium iodide, all obtained good results. All five kinds of known non-drag drugs were ineffective. The method used in this method combined with anatomical insects, do not need to set the control group, compared with foreign methods is simple and economical, and accurate and reliable .