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系统性红斑狼疮(systemic lupus erythematosus,SLE)是一种侵犯全身多系统、多脏器的自身免疫性疾病,儿童SLE的发病率约为0.6/10万[1]。该病主要是由遗传、环境和性激素等多因素引发机体免疫功能紊乱所致[2]。儿童SLE较成人严重,脏器受累率高,病情发展快,预后差[3]。虽目前该病无法治愈,但药物治疗对大部分患儿有效。过去10年中,患儿的存活率显著提高。SLE是一种慢性疾病,以缓解与复发反复交替为特征。在治疗过程中,病情常有复发,甚至部分患儿病情持续得不到缓解,复发和持续不缓解是儿童SLE较为棘手问题,也是关系成年期早期病
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that affects whole body, multiple systems and multiple organs. The incidence of SLE in children is about 0.6 / 100,000 [1]. The disease is mainly caused by genetic, environmental and sex hormones and other factors caused by immune dysfunction [2]. Children SLE more serious than adults, organ involvement rate, rapid progression, poor prognosis [3]. Although the disease can not be cured, but the drug treatment is effective in most children. Over the past 10 years, children’s survival rate increased significantly. SLE is a chronic disease characterized by repeated alternation of relapse and relapse. In the course of treatment, the disease often recurrence, and even some children’s condition continued to be alleviated, recurrence and sustained non-remission children SLE is more difficult problem, but also the relationship between early adult disease