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近年来儿童急性淋巴细胞性白血病的生存期延长,并发中枢神经系统白血病逐渐增多。本文作者对22例未经治疗的急性淋巴细胞性白血病患儿的脑脊液的离心液进行了过碘酸—雪夫氏(PAS)反应、苏丹黑染色、过氧化酶反应等组织化学检查,结果22例急性淋巴细胞性白血病患儿中发现4例有PAS阳性的原始淋巴细胞,而在瑞氏染色的脑脊液标本上没有检查出细胞增多或不典型的细胞,苏丹黑染色和过氧化酶反应呈阴性,PAS反应呈中度到显著反应。在临床追踪观察中,此4例患儿复查脑脊液,其中2例在诊断后3～5个月发生具有典型体征和症状的脑膜白血病,而另2例在预防性中枢神经放射治疗后,没有再查出PAS阳性的原始淋巴细胞,患儿持续完全缓解9～10
In recent years, the survival of children with acute lymphoblastic leukemia prolongs, and concurrent CNS leukemia gradually increased. In this study, 22 patients with untreated acute lymphoblastic leukemia in children with cerebrospinal fluid were subjected to periodic acid-Schiff (PAS) reaction, Sudan black staining, peroxidase reaction and other histochemical examination results 22 cases Four cases of PAS-positive primary lymphocytes were found in children with acute lymphoblastic leukemia, while no cells were observed in Wright’s staining cerebrospinal fluid samples. Sudan black staining and peroxidase reaction were negative, PAS reaction was moderate to significant response. In clinical follow-up, cerebrospinal fluid was rechecked in 4 patients, 2 of whom developed typical signs and symptoms of leukemia at 3 to 5 months after diagnosis, whereas the other 2 patients did not have recurrent CNS radiotherapy Found PAS-positive primitive lymphocytes, children continued to complete remission 9 ~ 10