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目的描述克-亚二氏综合征的脑部MRI表现,探讨MRI对该病的诊断价值。方法经病理证实的克-亚二氏综合征4例,回顾性分析其MRI和扩散加权像(DWI)表现,并复习相关临床及文献资料。结果1例表现为双侧脑室旁深部白质区及内囊后肢皮质脊髓束走行区稍长T1、稍长T2信号;2例T2WI及DWI上表现为双侧尾状核和壳核区对称性稍高信号影和部分皮质带状异常高信号;1例T2WI及DWI上表现为部分皮质带状异常高信号,伴脑萎缩。结论克-亚二氏综合征的脑部MRI表现有比较典型的特点,MRI是诊断该病的重要手段。
Objective To describe the brain MRI findings of Creutzfeldt-Jakob disease and to explore the diagnostic value of MRI in this disease. Methods Four patients with pathologically confirmed Creutzfeldt-Jakob disease were retrospectively analyzed for MRI and diffusion-weighted imaging (DWI), and the related clinical and literature data were reviewed. Results One case presented with slightly longer T1 and slightly longer T2 signals in the bilateral white matter of deep ventricle and the corticospinal tract of the posterior limb of the internal capsule. The T2WI and DWI showed the symmetry of bilateral caudate and putamen High signal intensity and some cortical abnormal high signal; 1 case of T2WI and DWI showed abnormal high cortical signal, with brain atrophy. Conclusions The brain MRI features of Creutzfeldt-Jakob syndrome are typical. MRI is an important method to diagnose the disease.