内皮素－1（ET－1）是一种具有血管收缩特性的多肽，已知在多种病理状态下和某些肿瘤病人中表现升高。它除具有血管收缩特性之外，尚可刺激不同类型细胞包括某些肿瘤细胞系的增生。为进一步估价ET－1在结肠直肠癌尤其是伴有肝转移者中的重要性，作者采用免疫组化、免疫电镜和血 Endothelin-1 (ET-1) is a polypeptide with vasoconstrictive properties known to be elevated in many pathological conditions and in certain tumor patients. In addition to its vasoconstrictive properties, it can stimulate the proliferation of different types of cells, including certain tumor cell lines. To further assess the importance of ET-1 in colorectal cancer, especially with liver metastases, the authors used immunohistochemistry, immunoelectron microscopy, and blood