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目的对湖南省人免疫缺陷病毒(HIV)感染者合并丙型肝炎病毒(HCV)、结核(TB)感染的情况进行流行病学调查和分析,评估合并感染的患病率及相关影响因素。方法对该省各医院2006—2008年收治的门诊和住院HIV感染病例,以统一的流行病学调查表进行登记;对各地区的现患HIV感染病例进行HCV抗体和TB抗体检测;用SPSS软件对不同因素下HIV合并HCV或TB感染的情况进行统计学分析。结果共调查978例病例,HIV合并HCV的感染率为33.95%(332例)。其中通过静脉吸毒感染HIV的患者合并HCV感染率为81.06%(321/396);30～44岁年龄组HIV合并HCV的感染率为42.60%(262/615);无业人员HIV合并HCV感染率为61.89%(302/488),上述3组HIV合并HCV感染率均明显高于其相关的其他各组(分别P<0.0125,P<0.0125,P<0.0045)。HIV合并TB的感染率为26.99%(264/978),其中静脉吸毒感染HIV者并发TB率35.86%明显高于性传播感染者的19.65%(P<0.0071);CD4+T淋巴细胞计数≤200个/μL组HIV患者合并TB率为41.59%,明显高于其他组(均P<0.(0125)。结论首次报告湖南省HIV合并HCV、TB的感染现状及其相关影响因素。静脉吸毒是HIV合并HCV感染的主要传播途径,30～44岁年龄组和无业人群合并感染率较高。HIV合并TB的感染率在CD4+T淋巴细胞计数≤200个/μL的HIV感染者中患病率较高。
Objective To investigate the epidemiological investigation and analysis of hepatitis C virus (HCV) and tuberculosis (TB) infection in Hunan Province among HIV-infected patients and to evaluate the prevalence and related factors of co-infection. Methods Outpatients and inpatients with HIV infection admitted to hospitals in the province from 2006 to 2008 were enrolled in a unified epidemiological questionnaire. HCV and TB antibodies were detected in HIV-infected cases in all regions of the province. SPSS software Statistical analyzes were performed on cases of HIV-infected or TB-infected HIV with different factors. Results A total of 978 cases were investigated. The prevalence of HIV infection was 33.95% (332 cases). Among them, HIV infection rate was 81.06% (321/396) in patients infected with HIV by intravenous injection and 42.60% (262/615) in HIV-infected patients in 30-44 age group. The HIV infection rate among HIV-positive patients and unemployed persons was 61.89% (302/488) respectively. The HCV infection rates of the three groups were significantly higher than those of other related groups (P <0.0125, P <0.0125, P <0.0045, respectively). The infection rate of HIV combined with TB was 26.99% (264/978). The incidence of TB complicated by HIV was 35.86%, which was significantly higher than that of sexually transmitted infections (19.65%) (P <0.0071). The CD4 + T lymphocyte count was less than 200 / ΜL group of HIV patients with combined TB rate was 41.59%, significantly higher than other groups (all P <0. (0125) .Conclusion The first report of HIV infection in Hunan Province, the status of HCV and TB infection and its related factors. HIV infection with HCV infection is the main route of transmission, 30 to 44 age group and unemployed people with higher infection rates .HIV combined with TB infection in the CD4 + T lymphocyte count ≤200 / HIV in HIV prevalence Higher.