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①目的 探讨良性前列腺增生（ＢＰＨ）组织中平滑肌成分的相对含量及与国际前列腺症状评分（ＩＰＳＳ）的相关性。②方法 应用免疫组织化学ＬＳＡＢ法，结合彩色病理图文分析系统，检测２０ 例ＢＰＨ和１０ 例正常前列腺组织中平滑肌成分占整个前列腺组织的相对含量。③结果 ＢＰＨ 组织中平滑肌细胞明显增生、肥大，弥漫地分布于间质中；正常前列腺组织中平滑肌细胞纤细，稀疏地分布在间质组织中。ＢＰＨ 组织中平滑肌成分占整个前列腺组织中的相对含量（２１．６０±１．４１）明显高于正常前列腺组织（１５．７３±１．８７），差异有极显著性（ｔ＝ ９．６４，Ｐ＜０．００１）。平滑肌成分的相对含量与ＢＰＨ病人ＩＰＳＳ呈正相关（ｒ＝ ０．７６６，Ｐ＜ ０．００１），与病人年龄无相关性。④结论ＢＰＨ组织中平滑肌成分的相对含量是影响ＢＰＨ临床表现的重要因素。
①Objective To investigate the relative content of smooth muscle components in benign prostatic hyperplasia (BPH) tissues and the correlation with International Prostate Symptom Score (IPSS). Methods The immunohistochemical LSAB method combined with color histogram analysis system was used to detect the relative content of smooth muscle in 20 cases of BPH and 10 cases of normal prostate tissue. ③ Results Smooth muscle cells in BPH tissues were hyperplasia, hypertrophy and diffusely distributed in stroma. Smooth muscle cells in normal prostate tissue were slender and sparsely distributed in interstitial tissues. The relative content of smooth muscle in BPH tissues (21.60 ± 1.41) was significantly higher than that in normal prostate tissues (15.73 ± 1.87), the difference was significant (t = 9.64, P <0.001). The relative content of smooth muscle components was positively correlated with IPSS in patients with BPH (r = 0.766, P <0.001), but not with patient age. ④ Conclusion The relative content of smooth muscle in BPH tissue is an important factor affecting the clinical manifestations of BPH.