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研究ＣＤ４４ｓ的表达与胃癌临床病理特征之间的关系，以明确ＣＤ４４ｓ在胃癌发展和预后中的作用。应用抗ＣＤ４４ｓ单克隆抗体免疫组化染色技术检测了９７例胃癌标本、结果显示部分正常胃腺体中下２／３的细胞膜和２３．７１％（２３／９７）的胃癌细胞被染成棕红色，免疫反应位于肿瘤细胞的胞膜上；硬癌ＣＤ４４ｓ表达率较高（Ｐ＜０．０５），浸润型胃癌ＣＤ４４ｓ强表达率较显著； ＣＤ４４ｓ表达与胃癌淋巴管浸润和淋巴结转移显著相关（Ｐ＜０． ０５）； ＣＤ４４ｓ强阳性表达胃癌患者术后５年生存率显著降低（ Ｐ＜０． ０５）。提示 ＣＤ４４ｓ异常表达可能参与了胃癌的发展并可能影响患者的预后。
The relationship between the expression of CD44s and the clinicopathological features of gastric cancer was studied to clarify the role of CD44s in the development and prognosis of gastric cancer. Immunohistochemical staining of anti-CD44s monoclonal antibody was used to detect 97 specimens of gastric cancer. The results showed that 2/3 of the normal gastric glands and 23.7 of the gastric mucosa and 23.71% (23/97) of gastric cancer cells were dyed brownish red. The immune response was located in the membrane of tumor cells; the expression rate of CD44s in hard cancer was higher (P<0.05), and the strong expression rate of invasive gastric cancer CD44s was more obvious; the expression of CD44s was significantly associated with lymphatic invasion and lymph node metastasis in gastric cancer (P <0. 05); The 5-year survival rate of CD44s strongly positive gastric cancer patients after surgery was significantly reduced (P<0.05). It is suggested that abnormal expression of CD44s may be involved in the development of gastric cancer and may affect the prognosis of patients.