The comparatively large mode field single-mode photonic crystal fibers (PCFs) were fabricated, the lightwave from 600- to 1600-nm wavelength along this PCF could be transmitted in single mode. The manufacturing process technologies of the PCFs were exploited, and the drawing parameters of PCFs were also presented. The structure parameters on the single-mode performance of PCFs were theoretically studied, and in practice the design was proved. The measurements of cut-off wavelength and light intensity distribution showed that the PCF had comparatively wide single-mode operating wavelength range.