论文部分内容阅读
对连翘叶水提取物和乙醇提取物的急性毒性进行初步研究。采用最大给药量测定法,小鼠灌胃给药测定连翘叶水提取物和乙醇提取物的半数致死量(LD50)或最大给药量,研究其安全性。连翘叶水提取物和乙醇提取物的毒性都很小,未测得LD50,水提取物和乙醇提取物最大给药量分别为48和42 g/kg体质量,在此剂量下小鼠无明显异常表现,内脏器官无异常,体质量与对照组无明显差异。结果表明:连翘叶无明显毒性,经口给药可安全用于兽医临床。
Acute toxicity of Forsythia suspensa leaf water extract and ethanol extract was studied. The maximum dose was used to determine the LD50 or the maximum dose of water extract and ethanol extract of Forsythia suspensa leaves by intragastric administration to study its safety. Forsythia leaf water extract and ethanol extract toxicity are very small, not measured LD50, water extract and ethanol extract maximum dose were 48 and 42 g / kg body weight at this dose in mice without Obvious abnormalities, no abnormal internal organs, body weight and the control group no significant difference. The results showed that: Forsythia leaves without obvious toxicity, oral administration can be safely used in veterinary clinical.