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目的:探讨热疗联合放疗在复发性卵巢癌治疗中的协同增敏作用。方法:68例晚期复发性卵巢癌患者,将其随机分为单纯放疗组(对照组)和热疗联合放疗组(实验组)。两组盆腔三维适形放疗单次剂量为200 c Gy,1次/日,5次/周。实验组在放疗结束后2小时内进行热疗,2次/周,共5周。治疗前及治疗结束后1个月均通过超声及CT检查对两组患者肿瘤体积的变化进行疗效评估,同时观察两组患者治疗后3年的生存情况。结果:近期疗效中发现,实验组11例完全缓解,17例部分缓解,对照组3例完全缓解,15例部分缓解,两组总有效率及完全缓解率差异均有统计学意义(P<0.05)。实验组3年总的生存率明显高于对照组,差异有统计学意义(P<0.05)。结论:热疗联合放疗可有效的杀灭复发的卵巢恶性肿瘤细胞,可缓解放疗副反应,明显提高患者的生存率。
Objective: To investigate the synergistic hypersensitivity effect of hyperthermia combined with radiotherapy in the treatment of recurrent ovarian cancer. Methods: Sixty-eight patients with advanced recurrent ovarian cancer were randomly divided into radiotherapy group (control group) and hyperthermia combined radiotherapy group (experimental group). The pelvic three-dimensional conformal radiotherapy single dose of 200 c Gy, 1 times / day, 5 times / week. The experimental group was treated with hyperthermia within 2 hours after radiotherapy, 2 times / week for 5 weeks. Before treatment and 1 month after the end of treatment, the curative effect of tumor volume was evaluated by ultrasound and CT examination. The survival of the two groups after 3 years of treatment was also observed. Results: In the short-term results, 11 cases were completely relieved in the experimental group and 17 cases were partly relieved. Three cases in the control group were completely relieved and 15 cases were partially relieved. The total effective rate and complete remission rate were significantly different between the two groups (P <0.05 ). The 3-year overall survival rate of the experimental group was significantly higher than that of the control group, with significant difference (P <0.05). Conclusion: Hyperthermia combined with radiotherapy can effectively kill the recurrence of ovarian cancer cells, which can relieve side effects of radiotherapy and significantly improve the survival rate of patients.