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本文进行了兔急性脑梗塞的磁共振灌注成像的实验研究，其研究内容是用兔急性脑梗塞模型，研究用造影剂和不用造影剂两种不同灌注成像方法的相关性，评价非造影剂灌注成像方法的有效性，并同时观察了兔急性脑梗塞在弥散加权成像、灌注加权成像和常规ＭＲＩ上的系列表现，以及经动脉溶栓的效果。初步研究结果表明，非造影剂灌注成像方法（ＦＡＩＲ序列）可以用于脑梗塞灌注评估；并结合ＤＷＩ、ＰＷＩ、Ｔ２ＷＩ能反映脑缺血的ＭＲ特征性演变过程以及相应的病理生理学信息。
In this study, rabbit acute cerebral infarction by magnetic resonance perfusion imaging experimental study, its research is the use of rabbit acute cerebral infarction model, with contrast agent and without contrast media two different perfusion imaging correlation, evaluation of non-contrast agent perfusion Imaging methods of effectiveness, and also observed the rabbit acute cerebral infarction in diffusion weighted imaging, perfusion weighted imaging and conventional MRI series performance, and the effect of thrombolysis through the artery. The preliminary results show that non-contrast agent perfusion imaging (FAIR sequence) can be used to evaluate cerebral perfusion. Combined with DWI, PWI and T2WI can reflect the characteristic evolution of cerebral ischemia and the corresponding pathophysiology information.