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目的：短期观察本那普利对临床糖尿病好病（DN）患者尿蛋白排泄和肾功能的影响。方法：16例临床DN患者在原抗糖尿病的基础上加用本那普利。结果：观察10～12周后，24h尿总蛋白、尿白蛋白及IgG排泄明显降低（P＜0．05），尿视黄酸结合蛋白排泄轻度降低，但有统计学差异；平均动脉压明显降低，但尿蛋白排泄的降低与血压下降无相关性；肾功能、空腹血糖和尿糖无明显变化。结论：本那普利对临床DN有较好的保护作用。
OBJECTIVE: To observe briefly the effect of Benazepril on urinary protein excretion and renal function in patients with clinically significant diabetic patients (DN). Methods: 16 patients with clinical DN were added Benazepril on the basis of the original antidiabetic. Results: After 10 to 12 weeks, urinary excretion of urinary albumin, albumin and IgG were significantly decreased (P <0.05), excretion of urinary retinoic acid slightly decreased, but the difference was statistically significant. Mean arterial pressure Was significantly lower, but decreased urinary protein excretion and no correlation between blood pressure; renal function, fasting blood glucose and urine sugar did not change significantly. Conclusion: Benazepril has a good protective effect on clinical DN.