作为一种具有重要免疫调节功能的细胞因子,IL-4对多种肿瘤细胞有较强的抑制和杀伤作用.体内外实验表明,这一效应的发挥是通过多途径的综合机制进行的,但以调动机体的细胞免疫机制为主.目前IL-4和毒素蛋白的融合蛋白对肿瘤的靶向杀伤及IL-4基因转移后的抗肿瘤作用已引起人们的注意和重视.尽管临床应用IL-4后存在一定副作用,但它仍具有很大的潜在应用价值. As an important immunoregulatory cytokine, IL-4 has strong inhibition and killing effect on a variety of tumor cells. In vivo and in vitro experiments show that this effect is exerted through a multi-path integrated mechanism, but The cell-mediated immunity mechanism of modulating the body is predominant. At present, the targeted killing of tumors by IL-4 and toxin protein fusion proteins and the antitumor effect of IL-4 gene transfer have attracted attention and attention. Despite the clinical application of IL- There are some side effects after 4, but it still has great potential application value.