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３１１例以顺铂和阿霉素联合方案化疗的恶性肿瘤患者，采用国产盐醚恩丹西酮与胃复安进行自身随机对照止吐研究。结果表明，恩丹西酮对顺铂联合方案引起的急性呕吐治疗，第１、２、３天有效率分别为９２．５％、８８．９％及８２．９％，明显优于胃复安的４２．２％、５６．３％及５９．３％（Ｐ＜０．０５）；恩丹西酮对阿霉素联合方案化疗引起的急性呕吐治疗，第１、２、３天有效率分别为９７．７％、９３．８％及９５．８％，而胃复安有效率为９２．０％、８４．１％及８１．３％。在副作用方面，恩丹西酮治疗组除便秘（４５例次．１１．７％）高于胃复安治疗组（且７例次，４．４％）外，无其它明显毒副反应；相反，胃复安治疗组中有７例（１．８％）发生锥体外系反应．而恩丹西酮治疗组中无一例出现。我们认为，恩丹西酮止吐疗效好，使用安全，尤其适合治疗顺铂类药物化疗所致的急性严重呕吐。
In 311 patients with malignant tumors treated with a combination of cisplatin and adriamycin chemotherapy, randomized controlled antiemetic studies with ondansetron and metoclopramide were conducted. The results showed that the effective rates of ondansetron for acute vomiting caused by cisplatin combination regimen were 92.5%, 88.9%, and 82.9% on days 1, 2 and 3, respectively. This was significantly better than metoclopramide. 42.2%, 56.3%, and 59.3% (P<0.05); Ondansetron was effective for the treatment of acute vomiting caused by adriamycin combined regimen chemotherapy on days 1, 2 and 3 It was 97.7%, 93.8%, and 95.8%, while the effective rates of metoclopramide were 92.0%, 84.1%, and 81.3%. In terms of side effects, except for constipation (45.11.7%) in the ondansetron treatment group, there was no other significant toxic side effect, compared with the metoclopramide treatment group (and 7 cases, 4.4%); In the metoclopramide treatment group, 7 cases (1.8%) had extrapyramidal reactions. No case occurred in the ondansetron treatment group. We believe that ondansetron antiemetic is effective and safe to use. It is especially suitable for the treatment of acute severe vomiting caused by cisplatin-based chemotherapy.