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用流式细胞光度计分析雌激素及其拮抗剂对 ER(+)和 ER(-)乳腺癌细胞的作用。所测结果表明:雌激素对 ER(+)乳腺癌细胞具有显著促分裂作用,而雌激素的拮抗剂三苯氧胺则能对抗这种促分裂作用;雌激素及其桔抗荆对 ER(-)乳腺癌细胞无显著作用。
The effects of estrogen and its antagonists on ER(+) and ER(-) breast cancer cells were analyzed by flow cytometry. The results showed that estrogen has a significant mitogenic effect on ER(+) breast cancer cells, while the antagonist estrogen, tamoxifen, is able to counteract this mitogenic effect; estrogen and its anticancer antagonist ER(-) breast Cancer cells have no significant effect.