论文部分内容阅读
目的探讨左氧氟沙星联合阿奇霉素治疗老年难治性呼吸道感染的疗效及安全性。方法选择2005年2月2010年9月收治的高龄难治性呼吸道细菌感染患者68例,随机分为治疗组和对照组。治疗组34例,给予左氧氟沙星联合阿奇霉素;对照组34例,给予左氧氟沙星,两组总疗程皆为15d。观察两组患者的临床疗效、细菌清除率和不良反应。结果治疗组的总有效率为64.71%,对照组总有效率为32.35%,两组差异有统计学意义(P<0.05)。治疗组细菌清除率为76.19%,对照组细菌清除率为36.36%,两组差异有统计学意义(P<0.05)。治疗组和对照组的不良反应发生率分别为5.88%和8.82%,差异无统计学意义(P>0.05)。结论左氧氟沙星联合阿奇霉素治疗老年难治性呼吸道感染疗效高,能有效清除细菌,不良反应较少,值得临床推广应用。
Objective To investigate the efficacy and safety of levofloxacin and azithromycin in the treatment of elderly refractory respiratory infections. Methods Sixty-eight elderly patients with refractory respiratory tract infection admitted in February 2005 and September 2010 were randomly divided into treatment group and control group. In the treatment group, 34 cases were treated with levofloxacin and azithromycin, while 34 cases in the control group were given levofloxacin. The total duration of treatment was 15 days. The clinical efficacy, bacterial clearance and adverse reactions of the two groups were observed. Results The total effective rate was 64.71% in the treatment group and 32.35% in the control group, with significant difference between the two groups (P <0.05). The bacterial clearance rate was 76.19% in the treatment group and 36.36% in the control group, with significant difference between the two groups (P <0.05). The incidence of adverse reactions in the treatment group and the control group were 5.88% and 8.82%, respectively, with no significant difference (P> 0.05). Conclusion Levofloxacin combined with azithromycin in the treatment of elderly patients with refractory respiratory tract infection has a high efficacy, can effectively remove bacteria, adverse reactions less worthy of clinical application.