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目的 :研究热休克蛋白 70 (HSP70 )在星形细胞瘤 (astrocytoma)中的表达与意义。方法 :采用鼠抗人 HSP70单克隆抗体及免疫组织化学 SABC法。结果 :在 99例星形细胞瘤中 ,HSP70表达 70例 (70 .7% ) ;用于对照的正常脑组织中 ,HSP70阳性仅 1例 (10 % )。HSP70在星形细胞瘤中的表达强于正常对照组 (P<0 .0 5) ,HSP70在 级和 级、 级和 级、 级和 级星形细胞瘤相互之间表达无显著性差异 (P>0 .0 5) ,但在 50例低度恶性星形细胞瘤 (WHO 级～ 级 )中表达强于在49例高度恶性星形细胞瘤 (WHO 级～ 级 )中的表达 (P<0 .0 5)。结论 :HSP70在大部分星形细胞瘤中有不同程度表达 ,HSP70可能参与星形细胞瘤的凋亡调变 ;其表达与星形细胞瘤分化有关
Objective: To study the expression and significance of HSP70 in astrocytoma. Methods: Mouse anti-human HSP70 monoclonal antibody and immunohistochemical SABC method were used. RESULTS: In 99 cases of astrocytomas, HSP70 expression was 70 (70.7%). Only 1 case (10%) of HSP70 was positive in normal brain tissue. The expression of HSP70 in astrocytoma was stronger than that in the normal control group (P <0.05), and there was no significant difference in the expression of HSP70 between grade and grade, grade, grade, grade and grade astrocytoma > 0.05), but was significantly higher in 50 cases of low grade astrocytoma (WHO grade ~ grade) than in 49 cases of high grade astrocytoma (WHO grade ~ P <0) .0 5). Conclusion: HSP70 is expressed in most degree in astrocytomas, and HSP70 may be involved in the apoptosis of astrocytoma. The expression of HSP70 may be related to the differentiation of astrocytoma