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目前常用的从绒毛或羊水穿刺中获取胎儿细胞进行产前诊断的方法有潜在的危险,使流产率增加0.5％。这就促进了对母血中寻找胎儿细胞方法的评估。正在实验的方法有流式细胞筛选法和磁化细胞筛选法(mag-netic-activated cell sorting,MACS)。这二种方法已成功地分离胎儿细胞并用于先天缺陷的产前诊断,如21三体的诊断。本研究采用一种新的方法分离胎儿细胞获得成功。 选择225例孕10～18周的孕妇,这些孕妇85％有遗传病家族史或筛选发现阳性及高龄。每例取静脉血15～16 ml,ACD抗凝,
Current methods commonly used to obtain fetal cells from villus or amniocentesis for prenatal diagnosis pose a potential risk of an abortion of 0.5%. This has facilitated the assessment of methods of finding fetal cells in maternal blood. The experimental methods are flow cytometry and mag-netic-activated cell sorting (MACS). Both of these methods have successfully isolated fetal cells and used for prenatal diagnosis of birth defects, such as the trisomy 21 diagnosis. This study used a new method to isolate fetal cells for success. Select 225 cases of pregnant 10 to 18 weeks of pregnant women, 85% of these pregnant women have a family history of genetic disease or screening found positive and elderly. Each case of venous blood taken 15 ~ 16 ml, anticoagulant ACD,