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设计成功了用无水酒精蒸气固定冰冻切片的冰冻微观放射自显影术,观察了信号核素~(134)Cs在体内呈离子态存在的定位行径。实验结果发现,~(134)Cs主要呈离子态均匀弥散定位于红细胞和白细胞中,在骨髓细胞中主要呈优势定位于幼稚细胞中,而在成熟细胞中则相对较少。在机体的软组织如骨骼肌,肝脏和大脑等部位,都可以见到~(134)Cs的摄入,而且可以较快进入软组织细胞内。应该指出的是,机体静脉摄入~(134)Cs 0.37～1.85kBq/g后的滞留,可使骨髓细胞和胸腺细胞的~3H-TdR参入率显著增升,表明其DNA合成能力增高,呈现对骨髓细胞与胸腺细胞的刺激增殖效应。
The frozen microscopic autoradiography was successfully designed to fix the frozen section with anhydrous alcohol vapor. The localization of the signal nuclide (134) Cs in the ionic state was observed. The experimental results showed that ~ (134) Cs mainly distributed in erythrocytes and leucocytes mainly in the ionic state, mainly located in immature cells in bone marrow cells, but relatively less in mature cells. In the body’s soft tissue such as skeletal muscle, liver and brain and other parts, can see ~ (134) Cs intake, and can quickly enter the soft tissue cells. It should be noted that the intakes of ~ (134) Cs 0.37 ~ 1.85kBq / g after intravenous ingestion of the body can significantly increase the ~ 3H-TdR incorporation rate of bone marrow cells and thymocytes, indicating that their DNA synthesis capacity is increased On bone marrow cells and thymocytes stimulated proliferation effect.