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在1-萘万古霉素手性固定相上分离了6种氨基醇类药物的对映体。考察了流动相中的酸、碱添加剂种类和浓度、溶质的化学结构对对映体分离的影响,同时探讨了手性识别机理。结果表明:普萘洛尔、比索洛尔、阿替洛尔、美托洛尔、索他洛尔和沙丁胺醇等6种药物的对映体在1-萘万古霉素手性柱上得到了完全分离,当甲醇流动相中冰乙酸和三乙胺添加剂量均为0.001%(体积分数)时,6种氨基醇的选择因子依次是1.16,1.36,1.15,1.10,1.18,1.16。
Enantiomers of six aminoalcohols were isolated on 1-naphtho vancomycin chiral stationary phase. The effects of acid and alkali additive types and concentrations in the mobile phase and the chemical structure of the solute on the separation of enantiomers were investigated. The chiral recognition mechanism was also discussed. The results showed that enantiomers of six drugs, propranolol, bisoprolol, atenolol, metoprolol, sotalol and salbutamol, were completely resolved on 1-naphtho vancomycin chiral columns When the additive amount of both glacial acetic acid and triethylamine in the methanol mobile phase was 0.001% (volume fraction), the selectivity factors of the six amino alcohols were 1.16, 1.36, 1.15, 1.10, 1.18, and 1.16, respectively.