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目的探讨大鼠脑干缺血的微创模型的建立方法及其局灶性脑水肿的诊断。方法在大鼠椎动脉进入椎体处用微银夹夹闭椎动脉的方法,建立可逆性脑干缺血模型,实时检测脑干诱发电位和电镜检查。结果本方法模型成功率达86．15%。缺血组Ⅰ、Ⅲ、Ⅴ波潜伏期值及Ⅰ～Ⅲ、Ⅲ～Ⅴ、Ⅰ～Ⅴ波峰同期值与对照组比较,缺血前差异无统计学意义(P＞0．05);缺血后0．5、1．0、1．5、2．0、2．5、4．0 h均非常显著延长(P＜0．01)。结论本组模型建立简便有效,使用脑干诱发电位可作为无创性脑干局灶性水肿的敏感诊断手段,临床及时诊断局灶性脑干有价值。
Objective To explore a method to establish a minimally invasive model of ischemic brain stem in rats and its diagnosis of focal cerebral edema. Methods The vertebral artery of vertebral artery was placed in the vertebral body with a micro silver clip to clamp the vertebral artery. A reversible brainstem ischemia model was established. The brainstem response and electron microscopy were detected in real time. Results The success rate of this method was 86.15%. Compared with the control group, the latency of Ⅰ, Ⅲ, Ⅴ and Ⅰ ~ Ⅴ peaks in group Ⅰ, Ⅲ and Ⅴ had no statistical significance (P> 0.05) 0.5,1.0,1.5,2.0,2.5,4.0 h were significantly longer (P <0.01). Conclusions This model is simple and effective. It can be used as a sensitive diagnostic method for noninvasive focal edema of the brainstem by using brain stem evoked potentials. It is valuable to diagnose focal brain stem in time.