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目的:为临床合理预防性应用抗菌药物提供参考。方法:对我院2006～2007年抗菌药物预防性应用失败病例进行监测,分析预防性用药失败原因,并对此期间临床送检标本进行病原微生物培养、分离、鉴定及细菌药敏试验,对结果进行耐药性分析。结果:头孢菌素类、喹诺酮类、青霉素类、头孢菌素类+酶抑制剂是我院临床预防性使用较多的抗菌药物,耐药率分别为57.21%、65.14%、68.63%、18.81%;监测病例240例,预防性应用抗菌药物877频次,其中388频次为无指征用药,占44.24%;耐药459频次,占52.34%;药物选择不恰当286频次,占32.61%;发生二重感染42例,发生率17.50%。结论:临床预防性使用抗菌药物存在较多问题,亟待加强规范化管理。
Objective: To provide a reference for the rational use of antibacterials in clinic. Methods: To monitor the failure of prophylactic use of antimicrobial agents in our hospital from 2006 to 2007, analyze the reasons for the failure of prophylactic drug use, and conduct the culture, isolation, identification and bacterial susceptibility testing of pathogenic microorganisms in clinical specimens during this period. Drug resistance analysis. Results: Cephalosporins, quinolones, penicillins and cephalosporins + enzyme inhibitor were the most effective antibacterial agents in our hospital. The rates of resistance were 57.21%, 65.14%, 68.63% and 18.81% ; 240 cases were monitored, 877 frequency of prophylactic use of antimicrobial drugs, of which 388 frequency for the non-indicted drug, accounting for 44.24%; resistance 459 frequency, accounting for 52.34%; drug selection is not appropriate 286 frequency, accounting for 32.61% Infection 42 cases, the incidence of 17.50%. Conclusion: There are many problems in the clinical use of antimicrobial drugs, and it is urgent to strengthen standardized management.