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本文报告了用单克隆抗体法及E—玫瑰花环法对比研究正常人及病毒性肝炎患者外周血T淋巴细胞亚群的初步结果。我国正常人外周血OKT_3~+、OKT_4~+及OKT_8~+三类T细胞的相对数量,总E(Et)及活性E(Ea)花环正常值均与文献报道极为接近。肝炎患者OKT_3~+,OKT_4~+及Et的相对值均明显减少,OKT_8~+及Ea的相对值均显著增高。这些患者外周血的淋巴细胞总绝对值较对照略有增加,QKT_8~+及OKT_4~+的绝对值增减不明显,OKT_8~+的绝对值显著增加。
This article reports the preliminary results of the comparison of peripheral blood T lymphocyte subsets between normal and viral hepatitis patients by the monoclonal antibody method and the E-rosette method. The relative numbers of OKT_3 ~ +, OKT_4 ~ + and OKT_8 ~ + T lymphocytes in normal people in China and the normal values of total E (Et) and active E (Ea) rosette are very close to those reported in the literature. The relative values of OKT_3 ~ +, OKT_4 ~ + and Et in hepatitis patients were significantly decreased, and the relative values of OKT_8 ~ + and Ea were significantly increased. The total absolute value of lymphocytes in peripheral blood of these patients increased slightly compared with the control. The absolute value of QKT_8 ~ + and OKT_4 ~ + was not significantly increased, but the absolute value of OKT_8 ~ + increased significantly.