本实验利用改良的Pulsinelli“大鼠模型,研究葡萄糖、胰岛素及山莨菪碱对血流再通后,缺血脑组织中的乳酸、葡萄糖、LPO、TXB_2及6-酮-PGF_(1α)含量的影响。结果:投用葡萄糖后,乳酸、LPO及TXB_2均明显增加,6-酮-PGF_(1α)明显减少;而投用胰岛素后,乳酸、LPO则明显减少,6-酮-PG_(1α)。明显增加;投用山茛菪碱后LPO及TXB_2明显减少。电镜检查发现,投用葡萄糖组的缺血性脑损害最为严重,而在其它组损害较轻。上述资料提示,葡萄糖可加重缺血性脑损害,而胰岛素及山莨菪碱对缺血脑组织具有保护作用。本文也讨论了这些药物的作用机制。 In this experiment, a modified Pulsinelli rat model was used to investigate the levels of lactate, glucose, LPO, TXB_2, and 6-keto-PGF_(1α) in ischemic brain tissue after glucose, insulin, and anisodamine were recanalized. Results: After administration of glucose, lactic acid, LPO and TXB 2 were significantly increased, and 6-keto-PGF 1 (1α) was significantly reduced, while insulin was administered, lactic acid and LPO were significantly reduced, 6-keto-PG_ (1α) Significantly increased; LPO and TXB 2 were significantly reduced after administration of anisodamine, and electron microscopy revealed that the ischemic brain damage in the glucose group was the most severe, while it was milder in other groups. Blood brain damage, while insulin and anisodamine have protective effects on ischemic brain tissue.The mechanism of action of these drugs is also discussed in this paper.